Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow. The anticancer activity is induced by xanthones such as alpha-, beta-, and gamma-mangostin which are major constituents of the pericarp of mangosteen fruits. In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction.

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The percentage of sub-G1 cells in the control group was 0. Medicinal properties of mangosteen Garcinia mangostana. The animals were housed in cages and allowed access to sterilized water and commercial rodent chow Biopia, Seoul, Korea ad libitum. Bao Q and Shi Y: Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines.

Mangostin | C24H26O6 – PubChem

Pharmacological effects of xanthones as cardiovascular protective agents. April Volume 37 Issue 4. Following incubation with the primary antibodies, mmangostin membranes were incubated with HRP-conjugated goat anti-rabbit IgG secondary antibodies for 2 h at room temperature with gentle shaking. DAPI staining was utilized to observe the cells by fluorescence microscopy. Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.

Apoptosis and the cell cycle.

Caspase activation and PARP cleavage are typical characteristics of apoptosis From the perspective of cell proliferation, cancer cells can be defined as being resistant to cell cycle control Membranes were incubated with anti-caspase-3, anti-caspase-9 and anti-PARP antibodies.


Mangosteen Garcinia mangostana L.

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Antimicrobial activities of Garcinia mangostana. Statistical significance was determined by the Dunnett’s t-test.

International Journal of Molecular Medicine 37, no. On day 22, mice were sacrificed and tumors excised. Bax and Bad are pro-apoptotic factors that promote apoptosis, whereas Bcl-2 is an anti-apoptotic factor 31 A comparative study of effects of aversectin C abamectin and ivermectin on apoptosis of rat thymo-cytes induced by radiation and dexamethasone.


The mitogen-activated protein kinase MAPK cascade, a pathway used to send external signals to internal cells, is involved in various processes, including cell proliferation and fragmentation, apoptosis and survival. The results of immunohistochemical analysis of cleaved caspase-3 were similar to those of western blot analysis Fig. Xanthone has also been widely used as an inhibitor of enzymes involved in the oxidation of low-density lipoprotein LDL cholesterol 13as well as those associated with infections, such as prostaglandin E 2 PGE 2 and cyclo-oxygenase-2 COX-2 The expression of c-myc also decreased.

J Agric Food Chem.

Mangostin – Wikipedia

Immunohistochemical analysis was also performed to examine the expression of Ki, the protein responsible for the rate of tumor growth Fig.

Moreover, the observed increases were concentration-dependent.

Oral cancer and precancerous lesions. Thus, surgical therapy, radiation and medication in combination are usually used to treat oral cancer; however, severe adverse effects and low treatment efficacy, as well as the ineffective inhibition of cancer cell growth and micrometastasis, results in patients with oral cancer tending to have a poor prognosis 5.


The MAPK signaling pathway is a core factor controlling various pathways, including cell growth, proliferation, segmentation and apoptosis. Thus far, various xanthones have been found in fruit, fruit skin, tree bark, moss and mold, and approximately 40 different xanthones have been found in the mangosstin fruit To identify Ki protein expression, immunohistochemistry was performed as described in the Material and methods.

All animal experiments were performed following the approval of the Institutional Animal Care and Use Committee according to the guidelines of Kongju National University. In other words, mangostih increase in the proportion of sub-G1 cells reflects an increase in apoptosis.

Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Both caspase-3 and -9 were activated, as evidenced by the increased levels of the respective cleaved forms, as well as PARP segmentation Fig.

To identify cleaved c -caspase-3 protein, immunohistochemcal staining was performed on tumor tissues collected from mouse xenografts as described in the Material and methods. Initiator caspases are activated by death signals to further activate the effector caspases